Biochemical markers in suicidal patients
Identifieur interne : 005027 ( Main/Exploration ); précédent : 005026; suivant : 005028Biochemical markers in suicidal patients
Auteurs : Csaba M. Banki [Hongrie] ; Mihály Arat [Canada] ; Zsuzsa Papp [Hongrie] ; Mihály Kurcz [Hongrie]Source :
- Journal of Affective Disorders [ 0165-0327 ] ; 1984.
English descriptors
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Abstract
Summary: 141 female psychiatric patients, suffering from major depression, schizophrenia, alcohol dependence or adjustment disorder, were investigated for their 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and cortisol level in the cerebrospinal fluid (CSF). Dexamethasone suppression tests were also performed in 111 cases, and TRH/TSH tests in 40 subjects. Fifty-two patients were hospitalized following a recent suicide attempt, 18 of which were made using a violent method. The other 34 attempters took tranquilizer or sedative overdoses.CSF 5-HIAA was significantly lower in violent attempters in all 4 diagnostic categories. CSF HVA was higher in those taking drug overdoses, but only in depression (and less markedly in schizophrenia). CSF cortisol did not differ among either diagnostic or suicidal subgroups. Dexamethasone suppression was more frequently abnormal in suicidal patients than in nonattempters, and this difference was more important where the overall nonsuppression rate was lower. Maximal TSH response to TRH showed an iverse correlation with CSF 5-HIAA, and it was lowest in the nonattempter group. The difference between violent suicide attempters and nonattempters in their TSH response was significant.Since these biochemical changes were more or less independent of clinical diagnoses, it seems relevant to explore further the biological background of human aggression and suicide as a separate research direction.
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DOI: 10.1016/S0165-0327(84)80012-9
Affiliations:
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Banki</name></author><author><name sortKey="Arat, Mihaly" sort="Arat, Mihaly" uniqKey="Arat M" first="Mihály" last="Arat">Mihály Arat</name></author><author><name sortKey="Papp, Zsuzsa" sort="Papp, Zsuzsa" uniqKey="Papp Z" first="Zsuzsa" last="Papp">Zsuzsa Papp</name></author><author><name sortKey="Kurcz, Mihaly" sort="Kurcz, Mihaly" uniqKey="Kurcz M" first="Mihály" last="Kurcz">Mihály Kurcz</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:635A41DE106B1409A7B0AF7EB308FE7BCE75AE58</idno><date when="1984" year="1984">1984</date><idno type="doi">10.1016/S0165-0327(84)80012-9</idno><idno type="url">https://api-v5.istex.fr/document/635A41DE106B1409A7B0AF7EB308FE7BCE75AE58/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002271</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002271</idno><idno type="wicri:Area/Istex/Curation">002271</idno><idno type="wicri:Area/Istex/Checkpoint">002594</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002594</idno><idno type="wicri:doubleKey">0165-0327:1984:Banki C:biochemical:markers:in</idno><idno type="wicri:Area/Main/Merge">005A39</idno><idno type="wicri:Area/Main/Curation">005027</idno><idno type="wicri:Area/Main/Exploration">005027</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Biochemical markers in suicidal patients</title><author><name sortKey="Banki, Csaba M" sort="Banki, Csaba M" uniqKey="Banki C" first="Csaba M." last="Banki">Csaba M. Banki</name><affiliation wicri:level="1"><country xml:lang="fr">Hongrie</country><wicri:regionArea>The Regional Neuropsychiatric Institute</wicri:regionArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Hongrie</country><wicri:regionArea>Correspondence to: Csaba M. Banki, M.D., P.O.B. 37, H-4321 Nagykàlló</wicri:regionArea><wicri:noRegion>H-4321 Nagykàlló</wicri:noRegion></affiliation></author><author><name sortKey="Arat, Mihaly" sort="Arat, Mihaly" uniqKey="Arat M" first="Mihály" last="Arat">Mihály Arat</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>McMaster University and Hamilton Psychiatric Hospital, Hamilton</wicri:regionArea><wicri:noRegion>Hamilton</wicri:noRegion></affiliation></author><author><name sortKey="Papp, Zsuzsa" sort="Papp, Zsuzsa" uniqKey="Papp Z" first="Zsuzsa" last="Papp">Zsuzsa Papp</name><affiliation wicri:level="1"><country xml:lang="fr">Hongrie</country><wicri:regionArea>National Institute for Nervous and Mental Diseases</wicri:regionArea></affiliation></author><author><name sortKey="Kurcz, Mihaly" sort="Kurcz, Mihaly" uniqKey="Kurcz M" first="Mihály" last="Kurcz">Mihály Kurcz</name><affiliation wicri:level="1"><country xml:lang="fr">Hongrie</country><wicri:regionArea>Chinoin Pharmaceuticals</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Affective Disorders</title><title level="j" type="abbrev">JAD</title><idno type="ISSN">0165-0327</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1984">1984</date><biblScope unit="volume">6</biblScope><biblScope unit="issue">3–4</biblScope><biblScope unit="page" from="341">341</biblScope><biblScope unit="page" to="350">350</biblScope></imprint><idno type="ISSN">0165-0327</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-0327</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>(5-HIAA)</term><term>(DST)</term><term>(HVA)</term><term>Adjustment disorder</term><term>Alcohol dependence</term><term>Cerebrospinal fluid amine metabolites</term><term>Major depression</term><term>Neuroendocrine tests</term><term>Schizophrenia</term><term>Sucide</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: 141 female psychiatric patients, suffering from major depression, schizophrenia, alcohol dependence or adjustment disorder, were investigated for their 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and cortisol level in the cerebrospinal fluid (CSF). Dexamethasone suppression tests were also performed in 111 cases, and TRH/TSH tests in 40 subjects. Fifty-two patients were hospitalized following a recent suicide attempt, 18 of which were made using a violent method. The other 34 attempters took tranquilizer or sedative overdoses.CSF 5-HIAA was significantly lower in violent attempters in all 4 diagnostic categories. CSF HVA was higher in those taking drug overdoses, but only in depression (and less markedly in schizophrenia). CSF cortisol did not differ among either diagnostic or suicidal subgroups. Dexamethasone suppression was more frequently abnormal in suicidal patients than in nonattempters, and this difference was more important where the overall nonsuppression rate was lower. Maximal TSH response to TRH showed an iverse correlation with CSF 5-HIAA, and it was lowest in the nonattempter group. The difference between violent suicide attempters and nonattempters in their TSH response was significant.Since these biochemical changes were more or less independent of clinical diagnoses, it seems relevant to explore further the biological background of human aggression and suicide as a separate research direction.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Hongrie</li></country></list><tree><country name="Hongrie"><noRegion><name sortKey="Banki, Csaba M" sort="Banki, Csaba M" uniqKey="Banki C" first="Csaba M." last="Banki">Csaba M. Banki</name></noRegion><name sortKey="Banki, Csaba M" sort="Banki, Csaba M" uniqKey="Banki C" first="Csaba M." last="Banki">Csaba M. Banki</name><name sortKey="Kurcz, Mihaly" sort="Kurcz, Mihaly" uniqKey="Kurcz M" first="Mihály" last="Kurcz">Mihály Kurcz</name><name sortKey="Papp, Zsuzsa" sort="Papp, Zsuzsa" uniqKey="Papp Z" first="Zsuzsa" last="Papp">Zsuzsa Papp</name></country><country name="Canada"><noRegion><name sortKey="Arat, Mihaly" sort="Arat, Mihaly" uniqKey="Arat M" first="Mihály" last="Arat">Mihály Arat</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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